"The word of the LORD also came to me, saying, “You shall not take a wife, nor shall you have sons or daughters in this place.” For thus says the LORD concerning the sons and daughters who are born in this place, and concerning their mothers who bore them and their fathers who begot them in this land: “They shall die gruesome deaths; they shall not be lamented nor shall they be buried, but they shall be like refuse on the face of the earth. They shall be consumed by the sword and by famine, and their corpses shall be meat for the birds of heaven and for the beasts of the earth.”(Jer. 16:1-4)
During a time when it was a shame and a dishonor to be single and childless, marriage and childbearing were expected. Jeremiah’s obedience to God’s command would attract attention. We should suppose that like most others Jeremiah looked for the blessings and benefits of marriage and parenthood. These were legitimate desires for him to have; yet in order to fulfill the call of God upon his life, he may need to deny such things to pursue the higher call. Jesus would later explain that His followers must be willing to deny themselves, take up their cross and follow Him (Luke 9:23). According to the will of God for the individual believer, this may mean giving up otherwise legitimate pursuits.(Guzik) Sacrificing blessings seem a little far fetched, but may be necessary to achieve more important spiritual goals.